Neonatal urticaria: Could it be CAPS?

Published Date: 24th September 2018

Publication Authors: Eustace K

​

Abstract

A neonatal boy presented with a persistent urticarial rash. Initial investigations showed raised inflammatory markers and evidence of systemic inflammation. A working diagnosis of cryopyrin‐associated periodic syndrome (CAPS) was made, and the patient responded extremely well to Anakinra. Molecular genetic testing revealed a somatic mutation (affecting 12.5% of cells) in the NLRP3 gene, accounting for the persistent inflammatory state but milder phenotype as seen in our patient.

 

Cutts, L; Parslew, R; Eustace, K. (2018). Neonatal urticaria: Could it be CAPS? . Pediatric Dermatology. epub 6 Sep

« Back