Neurocognitive Function of School-aged HIV-infected Children in Enugu, Nigeria

Published Date: 28th April 2017

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Abstract

Background

Evidence has shown neurocognitive problems often exist among human immunodeficiency virus (HIV)-infected children. There are limited data for children in Nigeria.

Methods

This was a cross-sectional study of 100 school-aged perinatally HIV-infected children seen in the paediatric HIV clinic and age/sex-matched controls from the general paediatric clinic. Neuro-cognitive functioning was assessed using the Raven’s progressive matrices (RPM) that has been adapted for the Nigerian population.

Results

The mean RPM score of subjects was 22.97 ± 11.35 compared with 32.93 ± 15.71 among controls (p < 0.001). Twenty-two percent of subjects in the HIV-infected group vs. 56% of controls were in the above-average intelligence group on the RPM. Thirty-four percent had average scores, while 22% were in the below-average scoring range. Neuro-cognitive functioning of the subjects was significantly affected by immunologic staging and socio-economic status.

Conclusions

Neurocognitive functioning of the HIV-infected children was significantly lower than those of their un-infected counterparts. Neurodevelopmental evaluation should be part of standard care in HIV-infected children in Nigerian setting.

Iloh, KK; Ilechukwu, GC et al. (2017). Neurocognitive Function of School-aged HIV-infected Children in Enugu, Nigeria . Journal of Tropical Pediatrics. epub 20 Feb

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