Pseudoangiomatous stromal hyperplasia

Published Date: 19th July 2016

Publication Authors: Barker D,

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INTRODUCTION

Pseudoangiomatous stromal hyperplasia (PASH) is a benign breast lesion that can be mistaken for angiosarcoma or fibroadenoma. This rare condition generally tends to present as a palpable mass in premenopausal women which can be seen on mammogram and ultrasound alike. The pathological findings tend to be of a thickening of the stroma and anastomosing channels arranged concentrically around the lobules.

METHOD

A literature search was carried out using SCOPUS, keywords Pseudoangiomatous, Stromal, Hyperplasia, or “PASH”. Relevant articles were obtained in full.

CONCLUSIONS

PASH appears to have hormonal influences and can be mistaken for breast cancer clinically and radiologically. A greater understanding of the histological appearances of PASH is key to attaining the correct diagnosis. FNAC is not adequate for this purpose - core biopsy or excision are recommended.

DISCUSSION

PASH is a benign condition. It can present a diagnostic challenge as it may mimic breast cancer both clinically and radiologically. Whilst there has been no definite proof of an association with invasive breast cancer PASH may be found in neighbouring tissue of invasive or in situ disease. There are currently no guidelines regarding follow up or management of patients with PASH. This article aims to increase the awareness of this rare condition and review the literature pertaining to the topic.

Pellegrini, A; Pennick, M; Barker, D; Audisio, RA. (2014).  Pseudoangiomatous Stromal Hyperplasia–A Summary of the Condition and Literature Review . Journal of OncoPathology. 2 (3), 55-62.

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