Delayed hypersensitivity to multiple glucocorticoid agents in a patient with cranial giant cell arteritis
Published Date: 09th November 2020
Publication Authors: Sze JT, Abernethy R
Extract
DEAR EDITOR, Hypersensitivity reactions to systemic glucocorticoids (GCs) are uncommon and paradoxical, because GCs are used to treat such reactions. The World Allergy Organization divides drug hypersensitivity reactions into immediate (occurring within 1 h of the administered dose) and delayed (appearing after 1 h, although most reactions start after 6 h). Immediate drug reactions, such as urticaria and anaphylaxis, after the administration of systemic GCs have been reported . These are IgE-mediated, type I reactions, which are potentially life threatening. Delayed, or type IV, reactions, in contrast, are T-cell mediated and tend to be caused by topical CSs. Delayed reactions to systemic GCs are rare, although their exact prevalence is unknown. To the best of our knowledge, there have not been any reported cases of hypersensitivity to GCs, immediate or delayed, in patients with GCA.
Sze, JT; Abernethy, R. (20). Delayed hypersensitivity to multiple glucocorticoid agents in a patient with cranial giant cell arteritis . Rheumatology Advances in Practice. 4 (2), rkaa064